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Pretreatment System
Medical Water Production Equipment
Multi-Effect Distillation Unit
Multi-Effect Water Distiller
Multi-Effect Water Distiller
Multi-Effect Water Distiller
Multi-Effect Water Distiller
Multi-Effect Water Distiller
Multi-Effect Water Distiller
Multi-Effect Water Distiller
Multi-Effect Water Distiller

Multi-Effect Water Distiller

Multiple effect stills for producing Water for Injection (WFI) in accordance with CP, USP and EP pharmacopoeias

The multi-effect water distiller is designed to use purified water as feed water and industrial steam as the heat source to produce Water for Injection (WFI) with high-purity. The WFI produced fully meets the stringent requirements of the Chinese Pharmacopoeia (CP 2020), United States Pharmacopeia (USP 43), and European Pharmacopoeia (EP 10), making it suitable for a wide range of pharmaceutical applications.

Applications

When combined with a reverse osmosis system, the multi-effect water distiller can be used to produce Water for Injection for human use and large-volume parenteral solutions. It is also well-suited for pharmaceutical manufacturing and hospital applications.

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Specifications
Model Capacity (L/h) Industrial Steam Consumption (L/h) Feed Water Consumption (L/h) Cooling Water Consumption (L/h) Dimensions (mm)
LDS100-4 ≥100 30 110 80 1080×585×2800
LDS300-5 ≥300 80 330 170 1760×755×3000
LDS500-5 ≥500 115 550 190 2000×805×3500
LDS1000-5 ≥1000 250 1100 350 2300×1000×4000
LDS1000-6 ≥1000 210 1100 0 2930×1000×4000
LDS2000-6 ≥2000 440 2200 0 3650×1200×4100
LDS3000-6 ≥3000 670 3300 0 3800×1200×4200
LDS4000-6 ≥4000 900 4400 0 4300×1250×4500
LDS5000-6 ≥5000 1130 5500 0 4600×1400×4600
LDS6000-6 ≥6000 1350 6600 0 4600×1400×4900

The production capacity ranges from 100–300 L/h for 4-effect models, 300–1500 L/h for 5-effect models, and 1500–6000 L/h for 6-effect models.

Note: The distillation unit is available in multiple-effect configurations to accommodate different production scales: 4-effect systems typically produce 100 to 300 liters per hour, 5-effect systems range from 300 to 1500 liters per hour, and 6-effect models deliver between 1500 and 6000 liters per hour.

Working Principle
Multi-Effect Water Distiller

Qualified feed water is pressurized by a multi-stage pump and first enters the condenser. It then passes sequentially through the preheaters of each effect. In the condenser, the feed water is heated by secondary steam and distilled water; as it flows through each preheater, it is further warmed by the condensate from the secondary steam. In the first-effect preheater, the feed water is heated by condensate from industrial steam. The preheated water then enters the first-effect evaporator, where it is evenly sprayed along the inner walls of the heating tubes by a water distributor. This creates a thin water film that flows down the tube walls and is vaporized by industrial steam. The resulting secondary steam, which may contain entrained water droplets, moves from the bottom of the evaporation chamber into a steam-water separation device. Here, pure steam is separated and sent to the next effect as the heating source, while any remaining feed water flows into the next effect. This process repeats across multiple effects.

Ultimately, the pure steam is condensed in the condenser, combined with condensate from other effects (except the first effect), and cooled. After non-condensable gases are vented (some models include continuous degassing devices on evaporators), the condensed water becomes Water for Injection. The outlet includes online conductivity monitoring; only distilled water that meets WFI specifications is discharged as final product, while non-conforming water is automatically drained.

Advantages
  • The six-effect model is designed to operate without the need for additional cooling water, that makes the utility requirements simpler and reduces the operating costs overall.
  • The distiller ensures stable and high-quality WFI production with adjustable output temperatures of 80–95°C, conductivity of 0.8 µS/cm, endotoxin level of 0.0625 EU/ml, and TOC below 20 ppb (achievable when feedwater meets CP 2020 purified water standards).
  • All shell-and-tube components, flanges, and other parts are manufactured in-house. Each component undergoes electropolishing to achieve a material contact surface roughness of ≤0.38 μm. Automated imported welding machines ensure precise and durable weld seams. Every unit undergoes a full FAT (Factory Acceptance Test) with aeration checks before shipment, ensuring safe operation and long service life.
  • Equipped with a fully automated Siemens control system, the distiller offers excellent scalability with options for remote modules, SCADA integration, and industrial PCs. This ensures seamless adaptability to different site conditions and operational requirements.
Multi-Effect Water Distiller
  • A

    Six-effect design, no cooling water required

  • B

    Steam consumption ratio adjustment: 0.21

  • C

    Feed water ratio adjustment: 1.08

  • Water Quality Indicators
  • 1

    Temperature: 95 ± 0.5°C

  • 2

    Conductivity: 0.8 µS/cm

  • 3

    Endotoxin: 0.0625 EU/ml

  • 4

    TOC: ﹤ 20 ppb

Features
  • The external preheater, condenser, and first-effect evaporator use a dual-tube sheet design with tube expansion and external welding techniques. This prevents cross-contamination between utility fluids and process water.
  • Equipped with a three-stage separation system, including falling-film evaporation, gravity separation, and helical swirling flow separation, ensuring high-purity steam output.
  • All parts in contact with feed water, Water for Injection, and secondary pure steam are made from SS316L stainless steel, ensuring corrosion resistance and pharmaceutical-grade hygiene.
  • Evaporators, preheaters, and condensers are insulated with aluminum silicate needle-punched blankets, offering excellent thermal performance, low weight, and high dimensional stability.
  • Internal and external surfaces are electropolished to maintain a smooth, easy-to-clean finish that meets pharmaceutical standards.
  • The multi-effect design reuses secondary steam across effects, achieving high steam utilization and significant energy savings. As the number of effects increases, energy efficiency improves, and cooling water usage decreases. Minimal cooling water is required for five-effect units, while six-effect units operate without cooling water.
  • Stainless steel pipes are formed with direct stretch bending to minimize welds. Where welding is required, argon-protected automatic welding with single-side welding and double-sided forming is used. Welds undergo electropolishing for superior hygienic quality.
  • Supplied with endoscopic inspection photos, weld point diagrams, pressure test reports, passivation records, and complete system design documentation for qualification and validation.
  • Automated HMI+PLC control with a user-friendly interface and multiple communication options. At least three access levels can be configured to manage operator permissions.
  • Real-time monitoring of conductivity, temperature, and flow. Data logging can be configured with either paperless or paper-based recorders to store and print critical parameters.
  • Optional electronic signatures and electronic records enable full audit trail capability. The control system is designed to comply with GAMP 5 guidelines and 21 CFR Part 11 requirements.

The multi-effect distillation unit uses purified water as feed water and industrial steam as the heat source to produce high-purity WFI. The six-effect model does not require additional cooling water. The produced WFI fully complies with CP 2020, USP 43, and EP 10 specifications, ensuring it meets the stringent purity requirements of pharmaceutical manufacturing.

Biotech labs have high requirements with the purity of water used and must avoid endotoxin contamination, especially during cell culture and reagent preparation. The advanced steam-water separation system in this distillation unit that operates effectively even with lower-grade feed water, reduces endotoxin formation. The six-effect design eliminates the need for additional cooling water, making it ideal for biotech laboratory applications.

Absolutely. The multi-effect distillation unit meets the regulatory standards of CP 2020, USP 43, and EP 10 for WFI. The six-effect model requires no additional cooling water, is easy to operate, offers a long service life, and ensures the high purity needed for clinical medical use.

Thanks to its multi-effect design, secondary steam is reused across multiple stages, achieving high energy efficiency. The five-effect model requires only a small amount of cooling water, while the six-effect model operates without any cooling water, reducing overall water usage while maintaining purity.